Gives account of inherited blindness in a family,

and observations contravening CD’s view in Variation that sheep and other domestic animals never run wild.

CD finds GB’s address interesting; assures him that he has never said GB was wrong on any point, but that there were differences between them, which he now thinks are not great.

Comments on specific parts of the address [see 6793]: colonisation, variability of large and small genera, descent from a single parent or pair of parents, rapid multiplication and change in species, isolation.

Asks CD to have stereotype plates made of new edition of Origin [5th English], if type still standing, though Appleton will reset type if necessary. Warns there is smaller audience in the U. S. for "good scientific books".

Appleton would also like plates made of new book [Descent] when possible.