His last letter to his mother, of 22 January 1787. His [and William Younge's] journey from Pisa to Rome, via Florence. Account of their time in Florence, where they were "quite in raptures"; art; the sepulchre of the Medicis; spent afternoons with Abbé Fontana. Stopped in Sienne to visit Dr Mascagni; his work on the lymphatic system. Their entrance into Rome; lodging in part of a house hired by Duke of Gloucester [Prince William Henry (1764-1805)]; compares St Peter's with St Paul's [Cathedral, London]; their itinerary.

Has learned all the particulars about Spalanzani, who "proves to be a great villain", having stolen items from the Emperor's museum and blamed Scopoli; further details of legal proceedings; many of his experiments found false; his father to inform relevant people.