CD has caused a great change in HS’s views, in showing how a great proportion of adaptation should be explained by natural selection not direct adaptation to changing conditions. HS had remarked on the survival of the best individuals as a cause of improvement in man, but he "& every one" overlooked selection of spontaneous variation. Believes so many kinds of indirect evidence must add up to a conclusive demonstration of the doctrine.

Wonders whether CD might contribute, if possible, an occasional letter to the Reader to help in their effort to establish the journal.

Asks whether CD will add his name to a list supporting them in the "[Edward John] Eyre prosecution matter".

Thanks CD for copy of Variation.

Discusses Pangenesis and considers CD’s "gemmules" comparable to his own hypothetical "physiological units" ["On alleged ""spontaneous generation"", and on the hypothesis of physiological units", appendix in The principles of biology, vol. 1 (1864)].