Suffering from a nervous debility caused by overwork; fears he will be unable to take up invitation to Norfolk. Preparing to publish a memoir of Monandrian plants and would like Smith's opinion on his figures. Received letter from [Nathaniel] Wallich giving an account of his expedition to Nepal and Singapore, the diseases he suffered, and the "immense acquisitions" he has made, which form the most valuable collection of living plants the Liverpool Botanic Garden has ever received, including 'Scitamineae' roots which are already shooting thanks to being packed in moss; he did not have time to write to Smith. Rejoices with Smith on marriage of his "amiable niece".

Visited Rev [John] Mitford, " a most liberal clergyman, learned & accomplished, a great friend of liberty, & a venerator of [Roscoe] & all [his] works", whilst staying with Lady [Pleasance] Smith's aunt in Saxmundham, [Suffolk]; he has a "choice garden" and a fine library, and is an elegant poet; offers Roscoe "important" papers on [Alexander] Pope.

Hopes to meet Roscoe at Holkham, [Norfolk, home of Thomas William Coke], where he can see Coke's "truly worthy lady" [Anne Amelia, nèe Keppel (1803-1844), Coke's recently married second wife]; dates for his intended visit; will attempt to introduce Mitford. Eager to discuss 'Scitamineae' plants with Roscoe. So pressed by his "[English] Flora" that he will have to work on the index at Holkham; currently on roses and briars.