Sends copies of his discourse on opening of the Liverpool Royal Institution for distribution. Details of two courses of lectures by [Thomas Stewart] Traill [(1781-1862), physician], on natural history, and Mr Campbell, on ancient and modern literature, from January to May; invites Smith to lecture in June and July, depending on his engagements. Taking an active part in public concerns of the Institution as a "counterpoise" to his troublesome business matters.

Asks when Smith can visit Liverpool, as [Thomas Stewart] Traill [(1781-1862), physician] finishes his course this week and Mr Campbell is not free to lecture until latter end of June, so the interval time is free for Smith's lectures. Explains the lecturer's fees, which are based on two guineas for each subscriber, with a certain amount being guaranteed. Will endeavour to have Smith nominated Professor of Botany. His business affairs continue to improve and will soon be reestablished.

Read Smith's Cambridge pamphlet with "equal impatience & pleasure"; believes it will eventually gain him the position [of botany professor]. Transcribes notice for the "Liverpool Mercury" announcing Smith's upcoming course of lectures on botany and vegetable physiology at Liverpool Royal Institution; requests further details from Smith; the subscription for non-proprieters will be two guineas. Sorry to hear Lady [Pleasance] Smith will not be accompanying Smith to Liverpool.

Describes his return journey from Liverpool, which included a stop at Matlock, [Derbyshire], to climb on Cromford Moor, "often celebrated in "English Botany"", for the first time since 1792; saw many lichens but concludes the dry summer has prevented their fructification. Has informed [Thomas William] Coke about Roscoe's intended visit. The Bishop of Winchester [Brownlow North] delighted by his Cambridge pamphlet; finds it curious that four Oxford bishops approve of his candidacy for Cambridge botany professorship.

Received a "curious work" by Sprengel ["Plantarum Umbelliferarum" (1813)] in which 'Umbelliferae' is reformed as successfully as 'Scitamineae' was by Roscoe; transcribes a Greek quote referring to himself. Encloses packet of New Holland fern seeds. Lists stipulations if the [Liverpool Royal] Institution should invite him to lecture again, would also stay two months to study the Botanic Garden for a long held project on garden plants.

[Letter possibly incomplete: no signature or valediction]