Intends to winter in Nice; also considered Florence and Pisa. His indisposition prevents him from settling at a university. Requests introductions and advice.

[Smith has noted his reply on verso of second folio]: comments climates of Nice, Florence, and Pisa, notes names of friends and accomodation recommendations.

Account of his time in Italy: spent time with Tozzetti at Florence, brings book/manuscript from him; compliments from Abbé Fontana; sending Scarpa's last publication; received great attention from Spallanzani including response to Hunter's queries on his animal digestion experiments.

His health did not benefit much by the Italian air [Boraston had wintered in Italy]; cold weather in Florence and Pisa; regrets not visiting Nice; inconvenience of making long journies alone. Left Spallanzani's response to Mr Hunter [on animal digestion] with Dr [William] Thomson [(c 1760-1806), mineralogist and physician]; many requests to peruse it. Will send impressions from Tozzetti of 'Fucus', described by Micheli, found near Florence. On his return through Milan visited Count Castiglioni, whose brother, Luigi, remembers meeting Smith; preparing history of plants and forest trees of North America; astonished by collections of the Milanese, particularly the Marquis d'Angubola's natural history collection; Societa Patriotica.

Still interested in medical news even though his medical studies long disrupted by his ill-health. His friends Dr Johnstone and son of Worcester wish to send their publications on nerves and poisons to European medical professors; asks for directions to Scarpa in Pavia.

Sends Dr Johnstone's books [on nerves and poisons] to be sent on to Scarpa. His health improved since marriage.