Enquires after Dr Savage and Lord Verney. Hopes that Smith has received the parcel he sent; as settlement of the debt will accept any small item for his "infant Musuem". Glad Smith is enjoying the company of Baron de la Tourbie, has heard a report that he wishes to marry the Prime Minister's daughter in order to get in the diplomatic body. News of mutual friends: Ippolito [Durazzo's] wife shall give birth soon; believes [William] Batt [(1744-1812) physician and chemist] shall settle in Genoa.

A great deal of sickness in Genoa in the winter "has swept away a prodigious amount of our inhabitants". None of [William] Batt's [(1744-1812) physician and chemist] patients died, earning him great credit but the plants in his botanic garden have all been frozen, asks Smith to procure whatever replacements he can. Sir Thomas Rumbold [(1736-1791) administrator of India] and his family have been visiting. Asks to pass apologies to Lord Verney should Smith see him. Thanks Smith for items sent for his little museum. Sending a collection of petrifications for Smith from Baron de la Turbie. Thanks for the "English songs", which are "very acceptable", and are to be sung at a wedding. Postscript from Caffarena's wife, explaining how her mother has been unable to write and thanking Smith for the English songs.

Comments on the petrified wood sent by Baron de la Turpie, who is now the King of Sardinia's ambassador to the Empress of Russia. Feels his advancing age. Introduces Mrs Langford, daughter of Thomas Sainsbury, Alderman of Billingsgate. Ippolito Durazzo's wife has recently given birth to a son. Caffarena's own youngest son wishes "serve his king and country in the navy".