Reminds CWC that he offered to give information with respect to his observations on hollyhocks. Wishes he could persuade CWC to undertake experiments on the fertility of some crosses between the most distinct varieties.

Has heard of mules of canary and other finches breeding occasionally, but it is rare, and there is hardly one authenticated case of two such mules breeding together.

Sixteen of the household at Down are sick with influenza.

Writes that [Murray’s] terms are very favourable; has never heard of such terms offered for a first work. HWB can depend on fact that Murray is pleased with it [The naturalist on the river Amazons].

Invitation to visit; Hooker will be present. Gives directions to Down. Also plans to invite John Lubbock over for an evening.

Quiz has had to be killed because he became vicious.

Horace Darwin strangely ill.

Thanks for letter and "valuable" extracts.

If S. American Carabi differ more from other species than do those from other distant locations (e.g., Siberia, Europe, etc.), CD agrees that difference would be too great to have occurred in the recent glacial age; CD also rejects independent origin. Plants seem to migrate more readily than animals. HWB should not underrate length of glacial period; CD also believes they will be driven to an older glacial period.

Sorry about news of British Museum – hopeless to contend against anyone supported by Owen.

CD dearly wishes HWB could find a situation in which he could give time to science.

Referring to conversation with Lyell, CD is certain that there was a Miocene glacial period.

Compliments HWB on the mimetic display at the British Museum. Those at the Museum readily accepted HWB’s "doctrine".

Was shown genital organs of closely allied Chrysomelidae.

Albert Günther is candidate for position at Museum.

Asks DO to identify a plant grown from earth adhering to the foot of a woodcock.

Asks for news of HWB and his book.

There has been sickness in CD’s family; one of the boys [and Emma] had scarlet fever.

Has had a letter from Edwin Brown of Burton who is working on classification of Carabi.

Thanks for last note. Assures HWB that all writers have problems similar to his.

Plans to inquire at Linnean Society for HWB’s paper.

His family, including Mrs Darwin and Leonard, are now well.

Thanks LB for copy of his Aus Natur und Wissenschaft [1862]. Responds to LB’s comment [on Origin].

Just finished HWB’s paper ["Contributions to an insect fauna of the Amazon valley", Trans. Linn. Soc. Lond. 23 (1862): 495–566], one of the most remarkable he has ever read. Found mimetic cases and connection of facts marvellous. Finds equally important the facts on variation and segregation of complete and semi-complete species. Questions whether insect mimicry is not due to small size and defencelessness. Criticises title of paper. Mentions that Wallace will appreciate it.

[Apparently in reply to question in missing portion of 3825.] A written agreement is unnecessary, but a letter stating terms would prevent misundertanding. He will attempt to have a review of HWB’s paper published.

Thanks for paper and references on variations [missing].

Regrets HWB’s trouble about artists, etc., saying such trouble is a law of nature.

Asks whether HWB has heard of starving Indians who are forced to cook in different ways, and eat new things.

Asks for any authentic cases of "sports", which CD calls "bud-variations". Flowers introduced from warmer temperate regions are said to be particularly apt to sport in this way.

CD now has proof that Cinchona is dimorphic and that some dimorphic plants are absolutely sterile with their own-form pollen.

Asks GHKT to examine or send pollen specimens of two Ceylon genera.

Asa Gray will try to get HWB’s paper reviewed.

Also mentions that he (CD) wrote a short review of it for Natural History Review [Collected papers 2: 87–92].

Asks whether bees or Lepidoptera visit flowers of Melastomataceae.

Congratulations on marriage, which CD considers the best and only chance for happiness in this world.

Glad HWB is near completion of book.

Begs him to thank Wallace for Melastoma information; CD "cannot endure being beaten by a beggarly flower".

CD relates Asa Gray’s pleasure over HWB’s paper and Gray’s plans to write abstract [Am. J. Sci. 2d ser. 36 (1863): 285–90].

Sends two spikes of Corydalis.

Admits he may have drawn false inference from MTM’s division of peloria into two classes.

Has finished vol. 1 [of Naturalist on the river Amazons]. CD praises book as "best ever published in England".

The review in the Athenæum was cold, as always, and insolent.